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Nico Melzer Selected Research

Autoimmune Diseases of the Nervous System

3/2022GABAA Receptor Autoantibodies Decrease GABAergic Synaptic Transmission in the Hippocampal CA3 Network.
11/2021The role of dendritic cells and their interactions in the pathogenesis of antibody-associated autoimmune encephalitis.
11/2021Rituximab Treatment and Long-term Outcome of Patients With Autoimmune Encephalitis: Real-world Evidence From the GENERATE Registry.
11/2021Intrathecal Antibody Production Against Epstein-Barr, Herpes Simplex, and Other Neurotropic Viruses in Autoimmune Encephalitis.
11/2021CSF Findings in Acute NMDAR and LGI1 Antibody-Associated Autoimmune Encephalitis.
11/2021Genome-wide Association Study Identifies 2 New Loci Associated With Anti-NMDAR Encephalitis.
1/2021Cross-reactivity of a pathogenic autoantibody to a tumor antigen in GABAA receptor encephalitis.
1/2020An expanded parenchymal CD8+ T cell clone in GABAA receptor encephalitis.
1/2019An Assay to Determine Mechanisms of Rapid Autoantibody-Induced Neurotransmitter Receptor Endocytosis and Vesicular Trafficking in Autoimmune Encephalitis.
1/2018Genetic predisposition in anti-LGI1 and anti-NMDA receptor encephalitis.
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Nico Melzer Research Topics

Disease

13Autoimmune Diseases of the Nervous System
03/2022 - 04/2016
8Multiple Sclerosis
01/2022 - 09/2008
7Encephalitis (Encephalitis, Rasmussen)
03/2022 - 05/2013
6Limbic Encephalitis (Paraneoplastic Limbic Encephalitis)
03/2022 - 01/2015
6Relapsing-Remitting Multiple Sclerosis
03/2022 - 03/2016
6Neoplasms (Cancer)
11/2021 - 01/2013
6Inflammation (Inflammations)
11/2021 - 09/2008
4Autoimmune limbic encephalitis
05/2022 - 01/2020
4Seizures (Absence Seizure)
03/2022 - 09/2017
4Anti-N-Methyl-D-Aspartate Receptor Encephalitis
11/2021 - 07/2017
3Epilepsy (Aura)
03/2022 - 09/2017
3Myasthenia Gravis
01/2022 - 01/2019
3Glioma (Gliomas)
11/2021 - 04/2016
3Central Nervous System Diseases (CNS Diseases)
07/2012 - 09/2009
2Status Epilepticus (Complex Partial Status Epilepticus)
03/2022 - 07/2019
2Disease Progression
03/2022 - 09/2008
2Infections
11/2021 - 01/2013
2Lymphoma (Lymphomas)
12/2019 - 01/2018
2Sepsis (Septicemia)
01/2019 - 01/2013
2Cerebellar Ataxia (Dysmetria)
01/2017 - 07/2012
2Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
11/2016 - 09/2008
1Genetic Predisposition to Disease (Genetic Predisposition)
03/2022
1Ataxia (Dyssynergia)
03/2022
1Type 1 Diabetes Mellitus (Autoimmune Diabetes)
03/2022
1Stiff-Person Syndrome (Stiff Man Syndrome)
03/2022
1Hemorrhagic Stroke
03/2022
1Myocardial Ischemia (Ischemic Heart Diseases)
03/2022
1Blood Vessel Dissection
03/2022
1Hemorrhage
03/2022
1Neurodegenerative Diseases (Neurodegenerative Disease)
01/2022
1Psychotic Disorders (Schizoaffective Disorder)
12/2021
1Brain Diseases (Brain Disorder)
11/2021
1Virus Diseases (Viral Diseases)
11/2021
1Neuroinflammatory Diseases
11/2021
1Central Nervous System Infections (Central Nervous System Infection)
11/2021
1Temporal Lobe Epilepsy
10/2021
1Deglutition Disorders (Dysphagia)
01/2021
1Hippocampal Sclerosis
10/2020
1Amnesia (Dissociative Amnesia)
01/2019
1Convalescence
01/2019
1Small Cell Lung Carcinoma (Small Cell Lung Cancer)
07/2018
1Primary angiitis of the central nervous system
01/2018
1Herpes Simplex
07/2017
1Progressive Multifocal Leukoencephalopathy
03/2017
1Multiple System Atrophy
01/2017
1Nervous System Diseases (Neurological Disorders)
01/2017
1Acute Cholecystitis
11/2016
1Transverse Myelitis (Necrotizing Myelitis)
08/2016
1Crohn Disease (Crohn's Disease)
08/2016

Drug/Important Bio-Agent (IBA)

14AntibodiesIBA
03/2022 - 07/2012
12AutoantibodiesIBA
03/2022 - 08/2016
7N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA
11/2021 - 04/2016
6Alemtuzumab (Campath)FDA Link
03/2022 - 03/2016
6Proteins (Proteins, Gene)FDA Link
12/2021 - 04/2016
5Glutamate Decarboxylase (Decarboxylase, Glutamate)IBA
03/2022 - 04/2016
5AntigensIBA
11/2021 - 05/2013
5Leucine (L-Leucine)FDA Link
11/2021 - 04/2016
4Protein Isoforms (Isoforms)IBA
03/2022 - 01/2015
3Rituximab (Mabthera)FDA Link
01/2022 - 07/2017
3Surface Antigens (Surface Antigen)IBA
01/2020 - 05/2013
2Aminobutyrates (Aminobutyric Acid)IBA
03/2022 - 06/2016
2HLA Antigens (Human Leukocyte Antigens)IBA
03/2022 - 11/2021
2gamma-Aminobutyric Acid (GABA)IBA
01/2021 - 01/2020
2T-Cell Antigen Receptors (T-Cell Receptor)IBA
01/2020 - 04/2016
2Immunoglobulin G (IgG)IBA
01/2019 - 08/2016
2Immunoglobulins (Immunoglobulin)IBA
07/2018 - 01/2018
2EnzymesIBA
11/2016 - 01/2015
2Adrenal Cortex Hormones (Corticosteroids)IBA
04/2016 - 03/2016
2CationsIBA
11/2014 - 01/2012
2Glutamic Acid (Glutamate)FDA Link
10/2013 - 09/2008
2Potassium Channels (Potassium Channel)IBA
09/2009 - 12/2008
1eculizumabFDA Link
01/2022
1ocrelizumabIBA
01/2022
1COVID-19 VaccinesIBA
01/2022
1Membrane Proteins (Integral Membrane Proteins)IBA
11/2021
1Neoplasm Antigens (Tumor Antigens)IBA
01/2021
1Edrophonium (Tensilon)FDA LinkGeneric
01/2021
1Voltage-Gated Potassium Channels (Voltage-Gated Potassium Channel)IBA
07/2020
1Prednisolone (Predate)FDA LinkGeneric
12/2019
1IgG Receptors (Fc gamma RI)IBA
12/2019
1Pharmaceutical PreparationsIBA
07/2019
1Cholinergic ReceptorsIBA
01/2019
1RhodaminesIBA
01/2019
1TeaIBA
01/2019
1Neurotransmitter Receptors (Neurotransmitter Receptor)IBA
01/2019
1CalciumIBA
09/2017
1Reactive Oxygen Species (Oxygen Radicals)IBA
09/2017
1Natalizumab (Tysabri)FDA Link
03/2017
1neurochondrinIBA
01/2017
1Matrix Metalloproteinase 2 (Gelatinase A)IBA
11/2016
1Matrix Metalloproteinase 9 (Gelatinase B)IBA
11/2016
1Matrix Metalloproteinases (MMPs)IBA
11/2016
1SteroidsIBA
08/2016

Therapy/Procedure

10Therapeutics
12/2021 - 09/2009
6Immunotherapy
05/2022 - 05/2013
1Immunomodulation
01/2022
1Plasma Exchange
12/2019
1Blood Component Removal (Apheresis)
10/2019
1Artificial Respiration (Mechanical Ventilation)
01/2019
1Tracheostomy
01/2019